The role of ferroptosis in intervertebral disc degeneration
Nucleus pulposus, annulus fibrosus, and cartilage endplate constitute an avascular intervertebral disc (IVD), which is crucial for spinal and intervertebral joint mobility. As one of the most widespread health issues worldwide, intervertebral disc degeneration (IVDD) is recognized as a key contribut...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-07-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2023.1219840/full |
| _version_ | 1827891865097076736 |
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| author | Chunyang Fan Genglei Chu Zilin Yu Zhongwei Ji Zhongwei Ji Fanchen Kong Lingye Yao Jiale Wang Dechun Geng Xiexing Wu Haiqing Mao |
| author_facet | Chunyang Fan Genglei Chu Zilin Yu Zhongwei Ji Zhongwei Ji Fanchen Kong Lingye Yao Jiale Wang Dechun Geng Xiexing Wu Haiqing Mao |
| author_sort | Chunyang Fan |
| collection | DOAJ |
| description | Nucleus pulposus, annulus fibrosus, and cartilage endplate constitute an avascular intervertebral disc (IVD), which is crucial for spinal and intervertebral joint mobility. As one of the most widespread health issues worldwide, intervertebral disc degeneration (IVDD) is recognized as a key contributor to back and neck discomfort. A number of degenerative disorders have a strong correlation with ferroptosis, a recently identified novel regulated cell death (RCD) characterized by an iron-dependent mechanism and a buildup of lipid reactive oxygen species (ROS). There is growing interest in the part ferroptosis plays in IVDD pathophysiology. Inhibiting ferroptosis has been shown to control IVDD development. Several studies have demonstrated that in TBHP-induced oxidative stress models, changes in ferroptosis marker protein levels and increased lipid peroxidation lead to the degeneration of intervertebral disc cells, which subsequently aggravates IVDD. Similarly, IVDD is significantly relieved with the use of ferroptosis inhibitors. The purpose of this review was threefold: 1) to discuss the occurrence of ferroptosis in IVDD; 2) to understand the mechanism of ferroptosis and its role in IVDD pathophysiology; and 3) to investigate the feasibility and prospect of ferroptosis in IVDD treatment. |
| first_indexed | 2024-03-12T21:32:27Z |
| format | Article |
| id | doaj.art-544bb419325b4bc995ab8441c33c2487 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-03-12T21:32:27Z |
| publishDate | 2023-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-544bb419325b4bc995ab8441c33c24872023-07-27T17:35:17ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2023-07-011110.3389/fcell.2023.12198401219840The role of ferroptosis in intervertebral disc degenerationChunyang Fan0Genglei Chu1Zilin Yu2Zhongwei Ji3Zhongwei Ji4Fanchen Kong5Lingye Yao6Jiale Wang7Dechun Geng8Xiexing Wu9Haiqing Mao10Department of Orthopaedic Surgery, Orthopaedic Institute, The First Affiliated Hospital, Suzhou Medical College, Soochow University, Suzhou, Jiangsu, ChinaDepartment of Orthopaedic Surgery, Orthopaedic Institute, The First Affiliated Hospital, Suzhou Medical College, Soochow University, Suzhou, Jiangsu, ChinaDepartment of Orthopaedic Surgery, Orthopaedic Institute, The First Affiliated Hospital, Suzhou Medical College, Soochow University, Suzhou, Jiangsu, ChinaDepartment of Orthopaedic Surgery, Orthopaedic Institute, The First Affiliated Hospital, Suzhou Medical College, Soochow University, Suzhou, Jiangsu, ChinaDepartment of Pain Management, Zhejiang Provincial People’s Hospital, People’s Hospital of Hangzhou Medical College, Hangzhou, Zhejiang, ChinaDepartment of Orthopaedic Surgery, Orthopaedic Institute, The First Affiliated Hospital, Suzhou Medical College, Soochow University, Suzhou, Jiangsu, ChinaDepartment of Orthopaedic Surgery, Orthopaedic Institute, The First Affiliated Hospital, Suzhou Medical College, Soochow University, Suzhou, Jiangsu, ChinaDepartment of Orthopaedic Surgery, Orthopaedic Institute, The First Affiliated Hospital, Suzhou Medical College, Soochow University, Suzhou, Jiangsu, ChinaDepartment of Orthopaedic Surgery, Orthopaedic Institute, The First Affiliated Hospital, Suzhou Medical College, Soochow University, Suzhou, Jiangsu, ChinaDepartment of Orthopaedic Surgery, Orthopaedic Institute, The First Affiliated Hospital, Suzhou Medical College, Soochow University, Suzhou, Jiangsu, ChinaDepartment of Orthopaedic Surgery, Orthopaedic Institute, The First Affiliated Hospital, Suzhou Medical College, Soochow University, Suzhou, Jiangsu, ChinaNucleus pulposus, annulus fibrosus, and cartilage endplate constitute an avascular intervertebral disc (IVD), which is crucial for spinal and intervertebral joint mobility. As one of the most widespread health issues worldwide, intervertebral disc degeneration (IVDD) is recognized as a key contributor to back and neck discomfort. A number of degenerative disorders have a strong correlation with ferroptosis, a recently identified novel regulated cell death (RCD) characterized by an iron-dependent mechanism and a buildup of lipid reactive oxygen species (ROS). There is growing interest in the part ferroptosis plays in IVDD pathophysiology. Inhibiting ferroptosis has been shown to control IVDD development. Several studies have demonstrated that in TBHP-induced oxidative stress models, changes in ferroptosis marker protein levels and increased lipid peroxidation lead to the degeneration of intervertebral disc cells, which subsequently aggravates IVDD. Similarly, IVDD is significantly relieved with the use of ferroptosis inhibitors. The purpose of this review was threefold: 1) to discuss the occurrence of ferroptosis in IVDD; 2) to understand the mechanism of ferroptosis and its role in IVDD pathophysiology; and 3) to investigate the feasibility and prospect of ferroptosis in IVDD treatment.https://www.frontiersin.org/articles/10.3389/fcell.2023.1219840/fullintervertebral disc degenerationferroptosislipid peroxidationantioxidant systemreactive oxygen speciesepigenetics |
| spellingShingle | Chunyang Fan Genglei Chu Zilin Yu Zhongwei Ji Zhongwei Ji Fanchen Kong Lingye Yao Jiale Wang Dechun Geng Xiexing Wu Haiqing Mao The role of ferroptosis in intervertebral disc degeneration Frontiers in Cell and Developmental Biology intervertebral disc degeneration ferroptosis lipid peroxidation antioxidant system reactive oxygen species epigenetics |
| title | The role of ferroptosis in intervertebral disc degeneration |
| title_full | The role of ferroptosis in intervertebral disc degeneration |
| title_fullStr | The role of ferroptosis in intervertebral disc degeneration |
| title_full_unstemmed | The role of ferroptosis in intervertebral disc degeneration |
| title_short | The role of ferroptosis in intervertebral disc degeneration |
| title_sort | role of ferroptosis in intervertebral disc degeneration |
| topic | intervertebral disc degeneration ferroptosis lipid peroxidation antioxidant system reactive oxygen species epigenetics |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2023.1219840/full |
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