Inhibition of the LRRC8A channel promotes microglia/macrophage phagocytosis and improves outcomes after intracerebral hemorrhagic stroke

Inhibition of the LRRC8A channel promotes microglia/macrophage phagocytosis and improves outcomes after intracerebral hemorrhagic stroke

Summary: Promoting microglial/macrophage (M/Mφ) phagocytosis accelerates hematoma clearance and improves the prognosis of intracerebral hemorrhagic stroke (ICH). Cation channels such as Piezo1 modulate bacterial clearance by regulating M/Mφ. Whether LRRC8A, an anion channel, affects M/Mφ erythrophag...

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Bibliographic Details
Main Authors: Jing Liu, Danmin Shen, Chao Wei, Weihua Wu, Zhaoli Luo, Liye Hu, Zhongnan Xiao, Tingting Hu, Qingyu Sun, Xiaotong Wang, Yumeng Ding, Meng Liu, Miaoyi Pang, Kaiyuan Gai, Yiran Ma, Yichen Tian, Yan Yu, Peipei Wang, Yun Guan, Meng Xu, Fei Yang, Qian Li
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:iScience
Subjects:
Immunology and neurology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222017990

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http://www.sciencedirect.com/science/article/pii/S2589004222017990

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