B cell intrinsic and extrinsic factors impacting memory recall responses to SRBC challenge

B cell intrinsic and extrinsic factors impacting memory recall responses to SRBC challenge

MBCs (MBCs) generated in T-dependent immune responses can persist for a lifetime and rapidly react upon secondary antigen exposure to differentiate into plasma cells (PCs) and/or to improve the affinity of their BCR through new rounds of hypermutation in germinal centers (GCs). The fate of a MBC in...

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Bibliographic Details
Main Authors: Viviana Valeri, Akhésa Sochon, Chaoliang Ye, Xinru Mao, Damiana Lecoeuche, Simon Fillatreau, Jean-Claude Weill, Claude-Agnès Reynaud, Yi Hao
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Immunology
Subjects:
germinal centers
plasma cells
GC persistence
serum antibodies
memory B cells
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.873886/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.873886/full

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