Delayed Oral LY333013 Rescues Mice from Highly Neurotoxic, Lethal Doses of Papuan Taipan (Oxyuranus scutellatus) Venom

Delayed Oral LY333013 Rescues Mice from Highly Neurotoxic, Lethal Doses of Papuan Taipan (Oxyuranus scutellatus) Venom

There is an unmet need for economical snakebite therapies with long shelf lives that are effective even with delays in treatment. The orally bioavailable, heat-stable, secretory phospholipase A2 (sPLA2) inhibitor, LY333013, demonstrates antidotal characteristics for severe snakebite envenoming in bo...

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Bibliographic Details
Main Authors: Matthew R. Lewin, José María Gutiérrez, Stephen P. Samuel, María Herrera, Wendy Bryan-Quirós, Bruno Lomonte, Philip E. Bickler, Tommaso C. Bulfone, David J. Williams
Format: Article
Language:English
Published: MDPI AG 2018-09-01
Series:Toxins
Subjects:
snakebite
envenoming
neglected tropical disease
field antidote
inhibitor
taipan
PLA2
phospholipase A2
neurotoxicity
antivenom
Online Access:http://www.mdpi.com/2072-6651/10/10/380

Internet

http://www.mdpi.com/2072-6651/10/10/380

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