Discovery of Quercetin and Its Analogs as Potent OXA-48 Beta-Lactamase Inhibitors

Discovery of Quercetin and Its Analogs as Potent OXA-48 Beta-Lactamase Inhibitors

Carbapenem resistance in Enterobacteriaceae caused by OXA-48 β-lactamase is a growing global health threat and has rapidly spread in many regions of the world. Developing inhibitors is a promising way to overcome antibiotic resistance. However, there are few options for problematic OXA-48. Here we i...

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Bibliographic Details
Main Authors: Yuejuan Zhang, Cheng Chen, Bin Cheng, Lei Gao, Chuan Qin, Lixia Zhang, Xu Zhang, Jun Wang, Yi Wan
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Pharmacology
Subjects:
antibiotic resistance
β-lactamase
OXA-48
inhibitor
flavonoid
quercetin
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.926104/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.926104/full

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