WWP1 inhibition increases SHP2 inhibitor efficacy in colorectal cancer

WWP1 inhibition increases SHP2 inhibitor efficacy in colorectal cancer

Abstract Protein tyrosine phosphatase SHP2 activates RAS signaling, which is a novel target for colorectal cancer (CRC) therapy. However, SHP2 inhibitor monotherapy is ineffective for metastatic CRC and a combination therapy is required. In this study, we aimed to improve the antitumor efficacy of S...

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Bibliographic Details
Main Authors: Hao Fan, Xuefei Hu, Fuao Cao, Leqi Zhou, Rongbo Wen, Hao Shen, Yating Fu, Xiaoming Zhu, Hang Jia, Zixuan Liu, Guimin Wang, Guanyu Yu, Wenjun Chang, Wei Zhang
Format: Article
Language:English
Published: Nature Portfolio 2024-07-01
Series:npj Precision Oncology
Online Access:https://doi.org/10.1038/s41698-024-00650-6

Internet

https://doi.org/10.1038/s41698-024-00650-6

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