Enhanced TLR-MYD88 Signaling Stimulates Autoinflammation in SH3BP2 Cherubism Mice and Defines the Etiology of Cherubism

Enhanced TLR-MYD88 Signaling Stimulates Autoinflammation in SH3BP2 Cherubism Mice and Defines the Etiology of Cherubism

Cherubism is caused by mutations in SH3BP2. Studies of cherubism mice showed that tumor necrosis factor α (TNF-α)-dependent autoinflammation is a major cause of the disorder but failed to explain why human cherubism lesions are restricted to jaws and regress after puberty. We demonstrate that the in...

Full description

Bibliographic Details
Main Authors: Teruhito Yoshitaka, Tomoyuki Mukai, Mizuho Kittaka, Lisa M. Alford, Salome Masrani, Shu Ishida, Ken Yamaguchi, Motohiko Yamada, Noriyoshi Mizuno, Bjorn R. Olsen, Ernst J. Reichenberger, Yasuyoshi Ueki
Format: Article
Language:English
Published: Elsevier 2014-09-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S221112471400686X

Internet

http://www.sciencedirect.com/science/article/pii/S221112471400686X

Similar Items