Magnitude and breadth of antibody cross-reactivity induced by recombinant influenza hemagglutinin trimer vaccine is enhanced by combination adjuvants

Abstract The effects of adjuvants for increasing the immunogenicity of influenza vaccines are well known. However, the effect of adjuvants on increasing the breadth of cross-reactivity is less well understood. In this study we have performed a systematic screen of different toll-like receptor (TLR)...

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Bibliographic Details
Main Authors: Jenny E. Hernandez-Davies, Emmanuel P. Dollinger, Egest J. Pone, Jiin Felgner, Li Liang, Shirin Strohmeier, Sharon Jan, Tyler J. Albin, Aarti Jain, Rie Nakajima, Algimantas Jasinskas, Florian Krammer, Aaron Esser-Kahn, Philip L. Felgner, Qing Nie, D. Huw Davies
Format: Article
Language:English
Published: Nature Portfolio 2022-06-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-12727-y