In Silico and In Vitro Study of Janus Kinases Inhibitors from Naphthoquinones

In Silico and In Vitro Study of Janus Kinases Inhibitors from Naphthoquinones

Janus kinases (JAKs) are involved in numerous cellular signaling processes related to immune cell functions. JAK2 and JAK3 are associated with the pathogenesis of leukemia and common lymphoid-derived illnesses. JAK2/3 inhibitors could reduce the risk of various diseases by targeting this pathway. He...

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Bibliographic Details
Main Authors: Kamonpan Sanachai, Panupong Mahalapbutr, Lueacha Tabtimmai, Supaphorn Seetaha, Nantawat Kaekratoke, Supakarn Chamni, Syed Sikander Azam, Kiattawee Choowongkomon, Thanyada Rungrotmongkol
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Molecules
Subjects:
JAK2/3 inhibitors
naphthoquinones
enzymatic and cell-based assay
molecular dynamics simulations
Online Access:https://www.mdpi.com/1420-3049/28/2/597

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https://www.mdpi.com/1420-3049/28/2/597

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