Structural Basis of the Interaction of the G Proteins, Gαi<sub>1</sub>, Gβ<sub>1</sub>γ<sub>2</sub> and Gαi<sub>1</sub>β<sub>1</sub>γ<sub>2</sub>, with Membrane Microdomains and Their Relationship to Cell Localization and Activity

Structural Basis of the Interaction of the G Proteins, Gαi<sub>1</sub>, Gβ<sub>1</sub>γ<sub>2</sub> and Gαi<sub>1</sub>β<sub>1</sub>γ<sub>2</sub>, with Membrane Microdomains and Their Relationship to Cell Localization and Activity

GPCRs receive signals from diverse messengers and activate G proteins that regulate downstream signaling effectors. Efficient signaling is achieved through the organization of these proteins in membranes. Thus, protein–lipid interactions play a critical role in bringing G proteins together in specif...

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Bibliographic Details
Main Authors: Rafael Álvarez, Pablo V. Escribá
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Biomedicines
Subjects:
drug discovery
lipid rafts
membrane lipids
palmitoylation
protein structure
protein prenylation
Online Access:https://www.mdpi.com/2227-9059/11/2/557

Internet

https://www.mdpi.com/2227-9059/11/2/557

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