Targeting two distinct epitopes on human CD73 with a bispecific antibody improves anticancer activity

Targeting two distinct epitopes on human CD73 with a bispecific antibody improves anticancer activity

Background Immunosuppressive extracellular adenosine is generated by the enzymatic activity of CD73. In preclinical models, antibodies (Abs) targeting different epitopes on CD73 exert anticancer activity through distinct mechanisms such as inhibition of enzymatic activity, engagement of Fc receptors...

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Bibliographic Details
Main Authors: Henrik J Ditzel, Christa E Müller, Odd L Gammelgaard, Mikkel G Terp, Christian Renn, Aran F Labrijn, Oliver Hamaker, Aaraby Y Nielsen, Henriette Vever, Soren WK Hansen, Morten F Gjerstorff, Paul WHI Parren
Format: Article
Language:English
Published: BMJ Publishing Group 2022-09-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/10/9/e004554.full

Internet

https://jitc.bmj.com/content/10/9/e004554.full

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