Histological and Somatic Mutational Profiles of Mismatch Repair Deficient Endometrial Tumours of Different Aetiologies

Histological and Somatic Mutational Profiles of Mismatch Repair Deficient Endometrial Tumours of Different Aetiologies

Background: Mismatch repair deficient (MMRd) tumours may arise from somatic events acquired during carcinogenesis or in the context of Lynch syndrome (LS), an inherited cancer predisposition condition caused by germline MMR pathogenic variants. Our aim was to explore whether sporadic and hereditary...

Full description

Bibliographic Details
Main Authors: Neil A. J. Ryan, Thomas D. J. Walker, James Bolton, Natalja ter Haar, Tom Van Wezel, Mark A. Glaire, David N. Church, D. Gareth Evans, Tjalling Bosse, Emma J. Crosbie
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Cancers
Subjects:
mismatch repair
lynch syndrome
somatic mutation
endometrial cancer
Online Access:https://www.mdpi.com/2072-6694/13/18/4538

Internet

https://www.mdpi.com/2072-6694/13/18/4538

Similar Items