Replenishing the malaria drug discovery pipeline: Screening and hit evaluation of the MMV Hit Generation Library 1 (HGL1) against asexual blood stage Plasmodium falciparum, using a nano luciferase reporter read-out

A central challenge of antimalarial therapy is the emergence of resistance to the components of artemisinin-based combination therapies (ACTs) and the urgent need for new drugs acting through novel mechanism of action. Over the last decade, compounds identified in phenotypic high throughput screens...

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Bibliographic Details
Main Authors:	Koen J. Dechering, Martijn Timmerman, Kim Rensen, Karin M.J. Koolen, Saman Honarnejad, Martijn W. Vos, Tonnie Huijs, Rob W.M. Henderson, Elodie Chenu, Benoît Laleu, Bailey C. Montefiore, Matthew D. Segall, James E.J. Mills, Eric M. Guantai, James Duffy, Maëlle Duffey
Format:	Article
Language:	English
Published:	Elsevier 2022-09-01
Series:	SLAS Discovery
Subjects:	Malaria High throughput screening Phenotypic screen Drug discovery Nanoluciferase Screening cascade
Online Access:	http://www.sciencedirect.com/science/article/pii/S2472555222136841

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http://www.sciencedirect.com/science/article/pii/S2472555222136841

Replenishing the malaria drug discovery pipeline: Screening and hit evaluation of the MMV Hit Generation Library 1 (HGL1) against asexual blood stage Plasmodium falciparum, using a nano luciferase reporter read-out

Internet

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