Mutation-class dependent signatures outweigh disease-associated processes in cystic fibrosis cells

Mutation-class dependent signatures outweigh disease-associated processes in cystic fibrosis cells

Abstract Background The phenotypic heterogeneity observed in Cystic Fibrosis (CF) patients suggests the involvement of other genes, besides CFTR. Here, we combined transcriptome and proteome analysis to understand the global gene expression patterns associated with five prototypical CFTR mutations....

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Bibliographic Details
Main Authors: Lúcia Santos, Rui Nascimento, Aires Duarte, Violeta Railean, Margarida D. Amaral, Patrick T. Harrison, Margarida Gama-Carvalho, Carlos M. Farinha
Format: Article
Language:English
Published: BMC 2023-02-01
Series:Cell & Bioscience
Subjects:
Cystic fibrosis
Disease signatures
Isogenic cell lines
Proteomics
Transcriptomics
Online Access:https://doi.org/10.1186/s13578-023-00975-y

Internet

https://doi.org/10.1186/s13578-023-00975-y

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