Rotating culture regulates the formation of HepaRG-derived liver organoids via YAP translocation

Rotating culture regulates the formation of HepaRG-derived liver organoids via YAP translocation

Abstract Background Liver organoid serves as an alternative model for liver pathophysiology in carbohydrate or lipid metabolism and xenobiotic metabolism transformation. Biomechanical cues including spaceflight mission can affect liver organoid construction and their related functions, but their und...

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Bibliographic Details
Main Authors: Shaoyu Zhong, Lu Zheng, Yi Wu, Shujin Sun, Qing Luo, Guanbin Song, Dongyuan Lü, Mian Long
Format: Article
Language:English
Published: BMC 2024-11-01
Series:BMC Biology
Subjects:
Liver organoids
HepaRG cells
Rotating Flat Chamber
Rotating culture
YAP
Mechanotransduction
Online Access:https://doi.org/10.1186/s12915-024-02062-1

Internet

https://doi.org/10.1186/s12915-024-02062-1

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