Pre-pandemic SARS-CoV-2-specific IFN-γ and antibody responses were low in Ugandan samples and significantly reduced in HIV-positive specimens

Pre-pandemic SARS-CoV-2-specific IFN-γ and antibody responses were low in Ugandan samples and significantly reduced in HIV-positive specimens

IntroductionWe investigated whether prior SARS-CoV-2-specific IFN-γ and antibody responses in Ugandan COVID-19 pre-pandemic specimens aligned to this population's low disease severity.MethodsWe used nucleoprotein (N), spike (S), NTD, RBD, envelope, membrane, SD1/2-directed IFN-γ ELISpots, and a...

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Bibliographic Details
Main Authors: Hellen Nantambi, Jackson Sembera, Violet Ankunda, Ivan Ssali, Arthur Watelo Kalyebi, Gerald Kevin Oluka, Laban Kato, Bahemuka Ubaldo, Freddie Kibengo, Joseph Ssebwana Katende, Ben Gombe, Claire Baine, Geoffrey Odoch, Susan Mugaba, Obondo James Sande, The COVID-19 Immunoprofiling Team, Pontiano Kaleebu, Jennifer Serwanga
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Immunology
Subjects:
SARS-CoV-2
Common-cold coronaviruses
sero-crossreactivity
Pre-existing IFN-γ
Sub-Saharan Africa
Disease severity
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1148877/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1148877/full

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