cGAMP the travelling messenger

2’3’-cGAMP is a key molecule in the cGAS-STING pathway. This cyclic dinucleotide is produced by the cytosolic DNA sensor cGAS in response to the presence of aberrant dsDNA in the cytoplasm which is associated with microbial invasion or cellular damage. 2’3’-cGAMP acts as a second messenger and activ...

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Bibliografski detalji
Glavni autori: Henry T. W. Blest, Lise Chauveau
Format: Članak
Jezik:English
Izdano: Frontiers Media S.A. 2023-05-01
Serija:Frontiers in Immunology
Teme:
Online pristup:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1150705/full