Natural variants suppress mutations in hundreds of essential genes

Natural variants suppress mutations in hundreds of essential genes

Abstract The consequence of a mutation can be influenced by the context in which it operates. For example, loss of gene function may be tolerated in one genetic background, and lethal in another. The extent to which mutant phenotypes are malleable, the architecture of modifiers and the identities of...

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Bibliographic Details
Main Authors: Leopold Parts, Amandine Batté, Maykel Lopes, Michael W Yuen, Meredith Laver, Bryan‐Joseph San Luis, Jia‐Xing Yue, Carles Pons, Elise Eray, Patrick Aloy, Gianni Liti, Jolanda van Leeuwen
Format: Article
Language:English
Published: Springer Nature 2021-05-01
Series:Molecular Systems Biology
Subjects:
compensatory evolution
genetic interactions
genetic modifiers
genetic suppression
natural variation
Online Access:https://doi.org/10.15252/msb.202010138

Internet

https://doi.org/10.15252/msb.202010138

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