miRNA-Dependent Regulation of AKT1 Phosphorylation

miRNA-Dependent Regulation of AKT1 Phosphorylation

The phosphoinositide-3-kinase (PI3K)/AKT pathway regulates cell survival and is over-activated in most human cancers, including ovarian cancer. Following growth factor stimulation, AKT1 is activated by phosphorylation at T308 and S473. Disruption of the AKT1 signaling pathway is sufficient to inhibi...

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Bibliographic Details
Main Authors: Mallory I. Frederick, Tarana Siddika, Pengcheng Zhang, Nileeka Balasuriya, Matthew A. Turk, Patrick O’Donoghue, Ilka U. Heinemann
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Cells
Subjects:
miRNA
posttranslational modification
protein phosphorylation
oncogenic kinase
signaling
Online Access:https://www.mdpi.com/2073-4409/11/5/821

Internet

https://www.mdpi.com/2073-4409/11/5/821

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