IL6 suppresses vaccine responses in neonates by enhancing IL2 activity on T follicular helper cells
Abstract The inability of neonates to develop CD4+FoxP3-CXCR5hiPD-1hi T follicular helper (TFH) cells contributes to their weak vaccine responses. In previous studies, we measured diminished IgG responses when IL-6 was co-injected with a pneumococcal conjugate vaccine (PCV) in neonatal mice. This is...
Main Authors: | , , , , , |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2023-11-01
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Series: | npj Vaccines |
Online Access: | https://doi.org/10.1038/s41541-023-00764-1 |