Enzymatic conversion of human blood group A kidneys to universal blood group O

Enzymatic conversion of human blood group A kidneys to universal blood group O

Abstract ABO blood group compatibility restrictions present the first barrier to donor-recipient matching in kidney transplantation. Here, we present the use of two enzymes, FpGalNAc deacetylase and FpGalactosaminidase, from the bacterium Flavonifractor plautii to enzymatically convert blood group A...

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Bibliographic Details
Main Authors: Serena MacMillan, Sarah A. Hosgood, Léonie Walker-Panse, Peter Rahfeld, Spence S. Macdonald, Jayachandran N. Kizhakkedathu, Stephen G. Withers, Michael L. Nicholson
Format: Article
Language:English
Published: Nature Portfolio 2024-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-47131-9

Internet

https://doi.org/10.1038/s41467-024-47131-9

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