A LY6E-PHB1-TRIM21 assembly degrades CD14 protein to mitigate LPS-induced inflammatory response

A LY6E-PHB1-TRIM21 assembly degrades CD14 protein to mitigate LPS-induced inflammatory response

Summary: A major theme of host against invading pathogens lies in multiple regulatory nodes that ensure sufficient signals for protection while avoiding excessive signals toward over-inflammation. The TLR4/MD-2/CD14 complex receptor-mediated response to bacterial lipopolysaccharide (LPS) represents...

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Bibliographic Details
Main Authors: Xinyu Zhu, Linxia Zhang, Daobin Feng, Lang Jiang, Peng Sun, Chen Zhao, Xiaoyan Zhang, Jianqing Xu
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:iScience
Subjects:
Immunology
Molecular biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223008854

Internet

http://www.sciencedirect.com/science/article/pii/S2589004223008854

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