Sumoylation of the Tumor Suppressor Promyelocytic Leukemia Protein Regulates Arsenic Trioxide-Induced Collagen Synthesis in Osteoblasts

Sumoylation of the Tumor Suppressor Promyelocytic Leukemia Protein Regulates Arsenic Trioxide-Induced Collagen Synthesis in Osteoblasts

Background/Aims: Promyelocytic leukemia (PML) protein is a tumor suppressor that fuses with retinoic acid receptor-α (PML-RARα) to contribute to the initiation of acute promyelocytic leukemia (APL). Arsenic trioxide (ATO) upregulates expression of TGF-β1, promoting collagen synthesis in osteoblasts,...

Full description

Bibliographic Details
Main Authors: Wen-Xiao Xu, Sheng-Zhi Liu, Di Wu, Guo-Fen Qiao, Jinglong Yan
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2015-11-01
Series:Cellular Physiology and Biochemistry
Subjects:
Promyelocytic leukemia
Sumoylation
Osteoblasts
Collagen synthesis
Arsenic trioxide
RNF4
UBC9
Online Access:http://www.karger.com/Article/FullText/438525

Internet

http://www.karger.com/Article/FullText/438525

Similar Items