Dose Optimization of Combined Linezolid and Fosfomycin against Enterococcus by Using an In Vitro Pharmacokinetic/Pharmacodynamic Model

Dose Optimization of Combined Linezolid and Fosfomycin against Enterococcus by Using an In Vitro Pharmacokinetic/Pharmacodynamic Model

ABSTRACT The rapid spread of antibiotic resistance among Enterococcus has prompted considerable interest in determining the dosage regimen of linezolid combined with fosfomycin. A checkerboard assay was employed to evaluate whether linezolid combined with fosfomycin had a synergistic effect on Enter...

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Bibliographic Details
Main Authors: Jun Mao, Ting Li, Na Zhang, Shuaishuai Wang, Yaowen Li, Yu Peng, Huiping Liu, Guang Yang, Yisong Yan, Lifang Jiang, Yanyan Liu, Jiabin Li, Xiaohui Huang
Format: Article
Language:English
Published: American Society for Microbiology 2021-12-01
Series:Microbiology Spectrum
Subjects:
linezolid
fosfomycin
PK/PD model
Enterococcus
combination therapy
Online Access:https://journals.asm.org/doi/10.1128/Spectrum.00871-21

Internet

https://journals.asm.org/doi/10.1128/Spectrum.00871-21

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