Hyaluronic Acid-Conjugated PLGA Nanoparticles Alleviate Ulcerative Colitis via CD44-Mediated Dual Targeting to Inflamed Colitis Tissue and Macrophages

Hyaluronic Acid-Conjugated PLGA Nanoparticles Alleviate Ulcerative Colitis via CD44-Mediated Dual Targeting to Inflamed Colitis Tissue and Macrophages

Although various local anti-inflammatory therapies for ulcerative colitis have been developed, rapid drug elimination from inflamed colitis tissue and off-target side effects reduce their therapeutic efficacy. In this study, we synthesized curcumin (Cur)-loaded hyaluronic acid (HA)-conjugated nanopa...

Full description

Bibliographic Details
Main Authors: Shwe Phyu Hlaing, Jiafu Cao, Juho Lee, Jihyun Kim, Aruzhan Saparbayeva, Dongmin Kwak, Hyunwoo Kim, Seonghwan Hwang, Hwayoung Yun, Hyung Ryong Moon, Yunjin Jung, Jin-Wook Yoo
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Pharmaceutics
Subjects:
ulcerative colitis therapy
inflamed tissue targeting
macrophage targeting
nanoparticle
hyaluronic acid
Online Access:https://www.mdpi.com/1999-4923/14/10/2118

Internet

https://www.mdpi.com/1999-4923/14/10/2118

Similar Items