METTL3 promotes prostatic hyperplasia by regulating PTEN expression in an m6A-YTHDF2-dependent manner

METTL3 promotes prostatic hyperplasia by regulating PTEN expression in an m6A-YTHDF2-dependent manner

Abstract Uncontrolled epithelial cell proliferation in the prostate transition zone and the hyper-accumulation of mesenchymal-like cells derived from the epithelial-mesenchymal transition (EMT) of prostatic epithelium are two key processes in benign prostatic hyperplasia (BPH). m6A RNA modification...

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Bibliographic Details
Main Authors: Jiaren Li, Hanyu Yao, Jin Huang, Chao Li, Yichuan Zhang, Ran Xu, Zhenting Wang, Zhi Long, Jin Tang, Long Wang
Format: Article
Language:English
Published: Nature Publishing Group 2022-08-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-022-05162-4

Internet

https://doi.org/10.1038/s41419-022-05162-4

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