Synthesis and antiproliferative activity of new thiazole hybrids with [3.3.0]furofuranone or tetrahydrofuran scaffolds

Synthesis and antiproliferative activity of new thiazole hybrids with [3.3.0]furofuranone or tetrahydrofuran scaffolds

New thiazole hybrids were synthesized and evaluated for their in vitro cytotoxicity against a panel of human malignant cell lines. The key steps in the synthesis of hybrids 3–7 involved the initial condensation of appropriate aldononitriles with cysteine ethyl ester hydrochloride, followed by subseq...

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Bibliographic Details
Main Authors: Kojić Vesna, Svirčev Miloš, Đokić Sanja, Kovačević Ivana, Rodić Marko V., Srećo-Zelenović Bojana, Popsavin Velimir, Popsavin Mirjana
Format: Article
Language:English
Published: Serbian Chemical Society 2023-01-01
Series:Journal of the Serbian Chemical Society
Subjects:
molecular hybridization
pseudo-c-nucleosides
goniofufurone
tiazofurin
analogues
antiproliferative activity
Online Access:https://doiserbia.nb.rs/img/doi/0352-5139/2023/0352-51392300002K.pdf

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https://doiserbia.nb.rs/img/doi/0352-5139/2023/0352-51392300002K.pdf

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