A study of the interaction space of two lactate dehydrogenase isoforms (LDHA and LDHB) and some of their inhibitors using proteochemometrics modeling

A study of the interaction space of two lactate dehydrogenase isoforms (LDHA and LDHB) and some of their inhibitors using proteochemometrics modeling

Abstract Lactate dehydrogenase (LDH) is a tetramer enzyme that converts pyruvate to lactate reversibly. This enzyme becomes important because it is associated with diseases such as cancers, heart disease, liver problems, and most importantly, corona disease. As a system-based method, proteochemometr...

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Bibliographic Details
Main Authors: Sedigheh Damavandi, Fereshteh Shiri, Abbasali Emamjomeh, Somayeh Pirhadi, Hamid Beyzaei
Format: Article
Language:English
Published: BMC 2023-07-01
Series:BMC Chemistry
Subjects:
Proteochemometrics
Machine learning algorithm
Isoenzyme
Camb package
Morgan fingerprints
Online Access:https://doi.org/10.1186/s13065-023-00991-6

Internet

https://doi.org/10.1186/s13065-023-00991-6

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