Pevonedistat, a NEDD8‐activating enzyme inhibitor, induces apoptosis and augments efficacy of chemotherapy and small molecule inhibitors in pre‐clinical models of diffuse large B‐cell lymphoma

Pevonedistat, a NEDD8‐activating enzyme inhibitor, induces apoptosis and augments efficacy of chemotherapy and small molecule inhibitors in pre‐clinical models of diffuse large B‐cell lymphoma

Abstract We studied the biological activity of pevonedistat, a first‐in‐class NEDD8‐activating enzyme (NAE) inhibitor, in combination with various cytotoxic chemotherapy agents and small molecule inhibitors in lymphoma preclinical models. Pevonedistat induced cell death in activated B‐cell (ABC) dif...

Full description

Bibliographic Details
Main Authors: Pallawi Torka, Cory Mavis, Shalin Kothari, Sarah Belliotti, Juan Gu, Suchitra Sundaram, Matthew Barth, Francisco J. Hernandez‐Ilizaliturri
Format: Article
Language:English
Published: Wiley 2020-07-01
Series:eJHaem
Subjects:
Apoptosis
MLN4924
NF‐κB
non‐Hodgkin lymphoma
ubiquitin proteasome system (UPS)
Online Access:https://doi.org/10.1002/jha2.2

Internet

https://doi.org/10.1002/jha2.2

Similar Items