Sharpin suppresses β1-integrin activation by complexing with the β1 tail and kindlin-1

Sharpin suppresses β1-integrin activation by complexing with the β1 tail and kindlin-1

Abstract Background Previously sharpin has been identified as an endogenous inhibitor of β1-integrin activation by directly binding to a conserved region in the cytoplasmic tails (CTs) of the integrin β1-associated α subunits. Methods Here we employed biochemical approaches and cellular analyses to...

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Bibliographic Details
Main Authors: Juan Gao, Yun Bao, Shushu Ge, Peisen Sun, Jiaojiao Sun, Jianmin Liu, Feng Chen, Li Han, Zhongyuan Cao, Jun Qin, Gilbert C. White, Zhen Xu, Yan-Qing Ma
Format: Article
Language:English
Published: BMC 2019-08-01
Series:Cell Communication and Signaling
Subjects:
Sharpin
Kindlin-1
Integrin
Talin
Online Access:http://link.springer.com/article/10.1186/s12964-019-0407-6

Internet

http://link.springer.com/article/10.1186/s12964-019-0407-6

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