An Absolutely Conserved Tryptophan in the Stem of the Envelope Protein E of Flaviviruses Is Essential for the Formation of Stable Particles

The major envelope protein E of flaviviruses contains an ectodomain that is connected to the transmembrane domain by the so-called “stem” region. In mature flavivirus particles, the stem is composed of two or three mostly amphipathic α-helices and a conserved sequence element (CS) with an undefined...

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Bibliographic Details
Main Authors: Iris Medits, Franz X. Heinz, Karin Stiasny
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Viruses
Subjects:
Online Access:https://www.mdpi.com/1999-4915/13/9/1727