Myeloid TLR4 signaling promotes post-injury withdrawal resolution of murine liver fibrosis

Myeloid TLR4 signaling promotes post-injury withdrawal resolution of murine liver fibrosis

Summary: The fate of resolution of liver fibrosis after withdrawal of liver injury is still incompletely elucidated. Toll-like receptor 4 (TLR4) in tissue fibroblasts is pro-fibrogenic. After withdrawal of liver injury, we unexpectedly observed a significant delay of fibrosis resolution as TLR4 sign...

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Bibliographic Details
Main Authors: Yoichi Takimoto, Po-sung Chu, Nobuhiro Nakamoto, Yuya Hagihara, Yohei Mikami, Kentaro Miyamoto, Rei Morikawa, Toshiaki Teratani, Nobuhito Taniki, Sota Fujimori, Takahiro Suzuki, Yuzo Koda, Rino Ishihara, Masataka Ichikawa, Akira Honda, Takanori Kanai
Format: Article
Language:English
Published: Elsevier 2023-03-01
Series:iScience
Subjects:
Immunity
Microbiome
Transcriptomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223002973

Internet

http://www.sciencedirect.com/science/article/pii/S2589004223002973

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