Dysregulation of the Lateral Habenula in Major Depressive Disorder

Dysregulation of the Lateral Habenula in Major Depressive Disorder

Clinical and preclinical evidence implicates hyperexcitability of the lateral habenula (LHb) in the development of psychiatric disorders including major depressive disorder (MDD). This discrete epithalamic nucleus acts as a relay hub linking forebrain limbic structures with midbrain aminergic center...

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Bibliographic Details
Main Authors: Caroline A. Browne, Robert Hammack, Irwin Lucki
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Synaptic Neuroscience
Subjects:
lateral habenula
major depressive disorder
behavior
optogenetic
reward
aversion
Online Access:https://www.frontiersin.org/article/10.3389/fnsyn.2018.00046/full

Internet

https://www.frontiersin.org/article/10.3389/fnsyn.2018.00046/full

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