The role of TGF-β and its crosstalk with RAC1/RAC1b signaling in breast and pancreas carcinoma

The role of TGF-β and its crosstalk with RAC1/RAC1b signaling in breast and pancreas carcinoma

Abstract This article focusses on the role of TGF-β and its signaling crosstalk with the RHO family GTPases RAC1 and RAC1b in the progression of breast and pancreatic carcinoma. The aggressive nature of these tumor types is mainly due to metastatic dissemination. Metastasis is facilitated by desmopl...

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Bibliographic Details
Main Authors: Catharina Melzer, Ralf Hass, Juliane von der Ohe, Hendrik Lehnert, Hendrik Ungefroren
Format: Article
Language:English
Published: BMC 2017-05-01
Series:Cell Communication and Signaling
Subjects:
Breast cancer
Pancreas cancer
Tumor cell signaling
Tumor microenvironment
TGF-β
Rac1
Online Access:http://link.springer.com/article/10.1186/s12964-017-0175-0

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http://link.springer.com/article/10.1186/s12964-017-0175-0

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