Deep Immune Phenotyping and Single-Cell Transcriptomics Allow Identification of Circulating TRM-Like Cells Which Correlate With Liver-Stage Immunity and Vaccine-Induced Protection From Malaria

Deep Immune Phenotyping and Single-Cell Transcriptomics Allow Identification of Circulating TRM-Like Cells Which Correlate With Liver-Stage Immunity and Vaccine-Induced Protection From Malaria

Protection from liver-stage malaria requires high numbers of CD8+ T cells to find and kill Plasmodium-infected cells. A new malaria vaccine strategy, prime-target vaccination, involves sequential viral-vectored vaccination by intramuscular and intravenous routes to target cellular immunity to the li...

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Bibliographic Details
Main Authors: Andrés Noé, Mehreen S. Datoo, Amy Flaxman, Mohammad Ali Husainy, Daniel Jenkin, Duncan Bellamy, Rebecca A. Makinson, Richard Morter, Fernando Ramos Lopez, Jonathan Sheridan, Dimitrios Voukantsis, Naveen Prasad, Adrian V. S. Hill, Katie J. Ewer, Alexandra J. Spencer
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-02-01
Series:Frontiers in Immunology
Subjects:
malaria vaccine
malaria vaccine decelopment
correlates of protection (CoP)
TRM
tissue resident memory CD8+ T cells
tissue resident memory T cell
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.795463/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.795463/full

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