Chromosomal Instability-Driven Cancer Progression: Interplay with the Tumour Microenvironment and Therapeutic Strategies

Chromosomal Instability-Driven Cancer Progression: Interplay with the Tumour Microenvironment and Therapeutic Strategies

Chromosomal instability (CIN) is a prevalent characteristic of solid tumours and haematological malignancies. CIN results in an increased frequency of chromosome mis-segregation events, thus yielding numerical and structural copy number alterations, a state also known as aneuploidy. CIN is associate...

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Bibliographic Details
Main Authors: Siqi Zheng, Erika Guerrero-Haughton, Floris Foijer
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Cells
Subjects:
chromosomal instability
tumour microenvironment
extracellular vesicles
cancer therapy
immune modulation
metabolic vulnerabilities
Online Access:https://www.mdpi.com/2073-4409/12/23/2712

Internet

https://www.mdpi.com/2073-4409/12/23/2712

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