Chromosomal Instability-Driven Cancer Progression: Interplay with the Tumour Microenvironment and Therapeutic Strategies
Chromosomal instability (CIN) is a prevalent characteristic of solid tumours and haematological malignancies. CIN results in an increased frequency of chromosome mis-segregation events, thus yielding numerical and structural copy number alterations, a state also known as aneuploidy. CIN is associate...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-11-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/12/23/2712 |
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| author | Siqi Zheng Erika Guerrero-Haughton Floris Foijer |
| author_facet | Siqi Zheng Erika Guerrero-Haughton Floris Foijer |
| author_sort | Siqi Zheng |
| collection | DOAJ |
| description | Chromosomal instability (CIN) is a prevalent characteristic of solid tumours and haematological malignancies. CIN results in an increased frequency of chromosome mis-segregation events, thus yielding numerical and structural copy number alterations, a state also known as aneuploidy. CIN is associated with increased chances of tumour recurrence, metastasis, and acquisition of resistance to therapeutic interventions, and this is a dismal prognosis. In this review, we delve into the interplay between CIN and cancer, with a focus on its impact on the tumour microenvironment—a driving force behind metastasis. We discuss the potential therapeutic avenues that have resulted from these insights and underscore their crucial role in shaping innovative strategies for cancer treatment. |
| first_indexed | 2024-03-09T01:53:45Z |
| format | Article |
| id | doaj.art-549acdc8b4d6470fb9642539b5e827a9 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-09T01:53:45Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-549acdc8b4d6470fb9642539b5e827a92023-12-08T15:13:08ZengMDPI AGCells2073-44092023-11-011223271210.3390/cells12232712Chromosomal Instability-Driven Cancer Progression: Interplay with the Tumour Microenvironment and Therapeutic StrategiesSiqi Zheng0Erika Guerrero-Haughton1Floris Foijer2European Research Institute for the Biology of Ageing (ERIBA), University Groningen, University Medical Center Groningen, 9713 AV Groningen, The NetherlandsEuropean Research Institute for the Biology of Ageing (ERIBA), University Groningen, University Medical Center Groningen, 9713 AV Groningen, The NetherlandsEuropean Research Institute for the Biology of Ageing (ERIBA), University Groningen, University Medical Center Groningen, 9713 AV Groningen, The NetherlandsChromosomal instability (CIN) is a prevalent characteristic of solid tumours and haematological malignancies. CIN results in an increased frequency of chromosome mis-segregation events, thus yielding numerical and structural copy number alterations, a state also known as aneuploidy. CIN is associated with increased chances of tumour recurrence, metastasis, and acquisition of resistance to therapeutic interventions, and this is a dismal prognosis. In this review, we delve into the interplay between CIN and cancer, with a focus on its impact on the tumour microenvironment—a driving force behind metastasis. We discuss the potential therapeutic avenues that have resulted from these insights and underscore their crucial role in shaping innovative strategies for cancer treatment.https://www.mdpi.com/2073-4409/12/23/2712chromosomal instabilitytumour microenvironmentextracellular vesiclescancer therapyimmune modulationmetabolic vulnerabilities |
| spellingShingle | Siqi Zheng Erika Guerrero-Haughton Floris Foijer Chromosomal Instability-Driven Cancer Progression: Interplay with the Tumour Microenvironment and Therapeutic Strategies Cells chromosomal instability tumour microenvironment extracellular vesicles cancer therapy immune modulation metabolic vulnerabilities |
| title | Chromosomal Instability-Driven Cancer Progression: Interplay with the Tumour Microenvironment and Therapeutic Strategies |
| title_full | Chromosomal Instability-Driven Cancer Progression: Interplay with the Tumour Microenvironment and Therapeutic Strategies |
| title_fullStr | Chromosomal Instability-Driven Cancer Progression: Interplay with the Tumour Microenvironment and Therapeutic Strategies |
| title_full_unstemmed | Chromosomal Instability-Driven Cancer Progression: Interplay with the Tumour Microenvironment and Therapeutic Strategies |
| title_short | Chromosomal Instability-Driven Cancer Progression: Interplay with the Tumour Microenvironment and Therapeutic Strategies |
| title_sort | chromosomal instability driven cancer progression interplay with the tumour microenvironment and therapeutic strategies |
| topic | chromosomal instability tumour microenvironment extracellular vesicles cancer therapy immune modulation metabolic vulnerabilities |
| url | https://www.mdpi.com/2073-4409/12/23/2712 |
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