Synthesis, Formulation and Characterization of Immunotherapeutic Glycosylated Dendrimer/cGAMP Complexes for CD206 Targeted Delivery to M2 Macrophages in Cold Tumors

Synthesis, Formulation and Characterization of Immunotherapeutic Glycosylated Dendrimer/cGAMP Complexes for CD206 Targeted Delivery to M2 Macrophages in Cold Tumors

Anti-tumor responses can be achieved via the stimulation of the immune system, a therapeutic approach called cancer immunotherapy. Many solid tumor types are characterized by the presence of immune-suppressive tumor-associated macrophage (TAMs) cells within the tumor microenvironment (TME). Moreover...

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Bibliographic Details
Main Authors: Marija Petrovic, Alexandre Porcello, Stoyan Tankov, Oliwia Majchrzak, Martin Kiening, Annick Clara Laingoniaina, Tayeb Jbilou, Paul R. Walker, Gerrit Borchard, Olivier Jordan
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Pharmaceutics
Subjects:
PAMAM
cGAMP
CD206
M2 macrophage-targeted delivery
nanoparticle orthogonal characterization
Online Access:https://www.mdpi.com/1999-4923/14/9/1883

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https://www.mdpi.com/1999-4923/14/9/1883

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