Treatment with recombinant Sirt1 rewires the cardiac lipidome and rescues diabetes-related metabolic cardiomyopathy

Treatment with recombinant Sirt1 rewires the cardiac lipidome and rescues diabetes-related metabolic cardiomyopathy

Abstract Background Metabolic cardiomyopathy (MCM), characterized by intramyocardial lipid accumulation, drives the progression to heart failure with preserved ejection fraction (HFpEF). Although evidence suggests that the mammalian silent information regulator 1 (Sirt1) orchestrates myocardial lipi...

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Bibliographic Details
Main Authors: Sarah Costantino, Alessandro Mengozzi, Srividya Velagapudi, Shafeeq Ahmed Mohammed, Era Gorica, Alexander Akhmedov, Alessia Mongelli, Nicola Riccardo Pugliese, Stefano Masi, Agostino Virdis, Andreas Hülsmeier, Christian Matthias Matter, Thorsten Hornemann, Giovanni Melina, Frank Ruschitzka, Thomas Felix Luscher, Francesco Paneni
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Cardiovascular Diabetology
Subjects:
Metabolic cardiomyopathy
Sirt1
Lipidome
Diabetes
Cardiometabolic
Therapy
Online Access:https://doi.org/10.1186/s12933-023-02057-2

Internet

https://doi.org/10.1186/s12933-023-02057-2

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