Loss of the Nuclear Envelope Protein LAP1B Disrupts the Myogenic Differentiation of Patient-Derived Fibroblasts

Loss of the Nuclear Envelope Protein LAP1B Disrupts the Myogenic Differentiation of Patient-Derived Fibroblasts

Lamina-associated polypeptide 1 (LAP1) is a ubiquitously expressed inner nuclear membrane protein encoded by <i>TOR1AIP1</i>, and presents as two isoforms in humans, LAP1B and LAP1C. While loss of both isoforms results in a multisystemic progeroid-like syndrome, specific loss of LAP1B ca...

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Bibliographic Details
Main Authors: Gülsüm Kayman Kürekçi, Aybar C. Acar, Pervin R. Dinçer
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:International Journal of Molecular Sciences
Subjects:
LAP1
<i>TOR1AIP1</i>
nuclear envelope
myogenic differentiation
muscular dystrophy
Online Access:https://www.mdpi.com/1422-0067/23/21/13615

Internet

https://www.mdpi.com/1422-0067/23/21/13615

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