Inhibition of TRPV1 channels by a naturally occurring omega-9 fatty acid reduces pain and itch
TRPV1 channels are known to mediate pathological pain and itch. Here, the authors find a naturally occurring fatty acid, oleic acid, acts as a TRPV1 antagonist and can modulate capsaicin and histamine-mediated pain and itch response in mouse models.
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2016-10-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms13092 |