Time-Resolved Effect of Interferon-Alpha 2a on Activities of Nuclear Factor Kappa B, Pregnane X Receptor and on Drug Disposition Genes

Time-Resolved Effect of Interferon-Alpha 2a on Activities of Nuclear Factor Kappa B, Pregnane X Receptor and on Drug Disposition Genes

Interferon-alpha (IFN-α) is suggested to cause pharmacokinetic drug interactions by lowering expression of drug disposition genes through affecting the activities of nuclear factor kappa B (NF-ĸB) and pregnane X receptor (PXR). The time-resolved impact of IFN-α 2a (1000 U/mL; 5000 U/mL; 2 h to 30 h)...

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Bibliographic Details
Main Authors: Dirk Theile, Lelia Wagner, Cindy Bay, Walter Emil Haefeli, Johanna Weiss
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Pharmaceutics
Subjects:
interferon-alpha
pregnane X receptor
nuclear factor kappa B
cytochrome P-450 3A4
pharmacokinetic drug–drug interactions
Online Access:https://www.mdpi.com/1999-4923/13/6/808

Internet

https://www.mdpi.com/1999-4923/13/6/808

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