Acidic pH and divalent cation sensing by PhoQ are dispensable for systemic salmonellae virulence

Acidic pH and divalent cation sensing by PhoQ are dispensable for systemic salmonellae virulence

Salmonella PhoQ is a histidine kinase with a periplasmic sensor domain (PD) that promotes virulence by detecting the macrophage phagosome. PhoQ activity is repressed by divalent cations and induced in environments of acidic pH, limited divalent cations, and cationic antimicrobial peptides (CAMP). Pr...

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Bibliographic Details
Main Authors: Kevin G Hicks, Scott P Delbecq, Enea Sancho-Vaello, Marie-Pierre Blanc, Katja K Dove, Lynne R Prost, Margaret E Daley, Kornelius Zeth, Rachel E Klevit, Samuel I Miller
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-05-01
Series:eLife
Subjects:
Salmonella
bacterial pathogenesis
intracellular virulence
innate immunity
signal transduction
sensor kinase
Online Access:https://elifesciences.org/articles/06792

Internet

https://elifesciences.org/articles/06792

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