Participation of ATP-sensitive K+ channels in the peripheral antinociceptive effect of fentanyl in rats

Participation of ATP-sensitive K+ channels in the peripheral antinociceptive effect of fentanyl in rats

We examined the effect of several K+ channel blockers such as glibenclamide, tolbutamide, charybdotoxin (ChTX), apamin, tetraethylammonium chloride (TEA), 4-aminopyridine (4-AP), and cesium on the ability of fentanyl, a clinically used selective µ-opioid receptor agonist, to promote peripheral antin...

Full description

Bibliographic Details
Main Authors: A.R.A. Rodrigues, M.S.A. Castro, J.N. Francischi, A.C. Perez, I.D.G. Duarte
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 2005-01-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
Peripheral antinociception
Fentanyl
K+ channel
µ-Opioid receptor agonist
Glibenclamide
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000100014

Internet

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000100014

Similar Items