Aspergillus fumigatus transcription factor ZfpA regulates hyphal development and alters susceptibility to antifungals and neutrophil killing during infection.

Aspergillus fumigatus transcription factor ZfpA regulates hyphal development and alters susceptibility to antifungals and neutrophil killing during infection.

Hyphal growth is essential for host colonization during Aspergillus infection. The transcription factor ZfpA regulates A. fumigatus hyphal development including branching, septation, and cell wall composition. However, how ZfpA affects fungal growth and susceptibility to host immunity during infecti...

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Bibliographic Details
Main Authors: Taylor J Schoen, Dante G Calise, Jin Woo Bok, Morgan A Giese, Chibueze D Nwagwu, Robert Zarnowski, David Andes, Anna Huttenlocher, Nancy P Keller
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-05-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1011152

Internet

https://doi.org/10.1371/journal.ppat.1011152

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