Expression of Connexin43 Stimulates Endothelial Angiogenesis Independently of Gap Junctional Communication In Vitro

Expression of Connexin43 Stimulates Endothelial Angiogenesis Independently of Gap Junctional Communication In Vitro

Connexins (Cx) form gap junctions (GJ) and allow for intercellular communication. However, these proteins also modulate gene expression, growth, and cell migration. The downregulation of Cx43 impairs endothelial cell migration and angiogenetic potential. Conversely, endothelial Cx43 expression is up...

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Bibliographic Details
Main Authors: Christoph Koepple, Zizi Zhou, Lena Huber, Matthias Schulte, Kjestine Schmidt, Torsten Gloe, Ulrich Kneser, Volker Jürgen Schmidt, Cor de Wit
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:International Journal of Molecular Sciences
Subjects:
gap junctions
connexins
endothelial tube formation
human umbilical vein endothelial cells
cellular migration
Online Access:https://www.mdpi.com/1422-0067/22/14/7400

Internet

https://www.mdpi.com/1422-0067/22/14/7400

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