Proximity-enabled covalent binding of IL-2 to IL-2Rα selectively activates regulatory T cells and suppresses autoimmunity

Proximity-enabled covalent binding of IL-2 to IL-2Rα selectively activates regulatory T cells and suppresses autoimmunity

Abstract Interleukin-2 (IL-2) is a pleiotropic cytokine that orchestrates bidirectional immune responses via regulatory T cells (Tregs) and effector cells, leading to paradoxical consequences. Here, we report a strategy that exploited genetic code expansion-guided incorporation of the latent bioreac...

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Bibliographic Details
Main Authors: Bo Zhang, Jiaqi Sun, Yeshuang Yuan, Dezhong Ji, Yeting Sun, Yudong Liu, Shengjie Li, Xingxing Zhu, Xunyao Wu, Jin Hu, Qiu Xie, Ling Wu, Lulu Liu, Boyang Cheng, Yuanjie Zhang, Lingjuan Jiang, Lidan Zhao, Fei Yu, Wei Song, Min Wang, Yue Xu, Shiliang Ma, Yunyun Fei, Lihe Zhang, Demin Zhou, Xuan Zhang
Format: Article
Language:English
Published: Nature Publishing Group 2023-01-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-022-01208-3

Internet

https://doi.org/10.1038/s41392-022-01208-3

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