Metabolic Drug Response Phenotyping in Colorectal Cancer Organoids by LC-QTOF-MS

Metabolic Drug Response Phenotyping in Colorectal Cancer Organoids by LC-QTOF-MS

As metabolic rewiring is crucial for cancer cell proliferation, metabolic phenotyping of patient-derived organoids is desirable to identify drug-induced changes and trace metabolic vulnerabilities of tumor subtypes. We established a novel protocol for metabolomic and lipidomic profiling of colorecta...

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Bibliographic Details
Main Authors: Sylvia K. Neef, Nicole Janssen, Stefan Winter, Svenja K. Wallisch, Ute Hofmann, Marc H. Dahlke, Matthias Schwab, Thomas E. Mürdter, Mathias Haag
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Metabolites
Subjects:
metabolomics
lipidomics
metabolic profiling
organoids
colorectal cancer
QTOF
Online Access:https://www.mdpi.com/2218-1989/10/12/494

Internet

https://www.mdpi.com/2218-1989/10/12/494

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