Alpha globin gene copy number and hypertension risk among Black Americans.

Alpha globin gene copy number and hypertension risk among Black Americans.

<h4>Background</h4>Alpha globin is expressed in the endothelial cells of human resistance arteries where it binds to endothelial nitric oxide synthase and limits release of the vasodilator nitric oxide. Genomic deletion of the alpha globin gene (HBA) is common among Black Americans and c...

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Bibliographic Details
Main Authors: A Parker Ruhl, Neal Jeffries, Yu Yang, Orlando M Gutierrez, Paul Muntner, Rakhi P Naik, Lydia H Pecker, Bryan T Mott, Neil A Zakai, Monika M Safford, Leslie A Lange, Cheryl A Winkler, Marguerite R Irvin, Mary Cushman, Hans C Ackerman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0271031

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https://doi.org/10.1371/journal.pone.0271031

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