Tumor-targeted superantigens produce curative tumor immunity with induction of memory and demonstrated antigen spreading

Tumor-targeted superantigens produce curative tumor immunity with induction of memory and demonstrated antigen spreading

Abstract Background Despite remarkable progress, the immunotherapies currently used in the clinic, such as immune checkpoint blockade (ICB) therapy, still have limited efficacy against many types of solid tumors. One major barrier to effective treatment is the lack of a durable long-term response. T...

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Bibliographic Details
Main Authors: Meir Azulay, Michal Shahar, Eitan Shany, Eti Elbaz, Sveta Lifshits, Marie Törngren, Adam Friedmann, Robert Kramer, Gunnar Hedlund
Format: Article
Language:English
Published: BMC 2023-03-01
Series:Journal of Translational Medicine
Subjects:
Naptumomab estafenatox
Immune checkpoint inhibitors
Programmed cell death 1 receptor
T-cell receptors
Memory T lymphocytes
Immunotherapy
Online Access:https://doi.org/10.1186/s12967-023-04064-z

Internet

https://doi.org/10.1186/s12967-023-04064-z

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